Discovering transformational therapies

Maxion Therapeutics

Mission

KnotBody®

Inspired by nature,
enhanced by innovation.

KnotbodyIon channel and GPCR-driven diseases

KnotBody® Technology

Using our revolutionary KnotBody® technology, we are creating first-in-class and best-in-class protein therapeutics for treating previously untreatable ion channel and GPCR-driven diseases.

Antibody based drugs can be a game changer

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Chronic Pain

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It affects ~1.5 billion people worldwide and ~64% of patients on the current pain medications are inadequately treated.

Autoimmunity

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More than 300 million people worldwide suffer from autoimmune disorders.

Cardiovascular disease

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Cardiovascular disease is the leading cause of death globally.

Ion channel and GPCR disfunction are implicated in a wide range of debilitating diseases and current treatments based on small molecule drugs suffer from poor efficacy and side effects.

Compared to small molecules, engineered antibodies offer vastly superior selectivity and are well proven therapeutically, representing 7/10 of top-selling drugs.

Despite these obvious advantages, antibody discovery against ion channel and GPCRs has been challenging.

Opportunity

Technology

Natural evolution meets directed evolution.

Blue antibody structure with two arms and a central hinge, illustrating a Y-shaped protein involved in immune response.

KnotBody®

Inspired by nature

By fusing naturally occurring cysteine-rich miniproteins (‘Knottins’) into antibody binding loops, our patented KnotBody® technology combines the power of millions of years of Knottin evolution in targeting ion channels and GPCRs with state-of-the-art antibody engineering techniques, addressing key challenges in ion channel and GPCR drug discovery.

KnotBody®

Enhanced by innovation

Multifunctionality

Arrow

Potency and Selectivity

Half-life & Manufacturability

Multifunctionality

Potency & Selectivity

Arrow

Half-life & manufacturability

We are leveraging this technology to deliver safe, efficacious and long-acting drugs against previously undruggable targets.

TEAM

Maxion is founded and led by an experienced team with an excellent track record

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Arndt Schottelius, MD, PhD

Arndt Schottelius, MD, PhD

CEO

John McCafferty, PhD

John McCafferty, PhD

Co-founder and CTO

Aneesh Karatt-Vellatt, PhD

Aneesh Karatt-Vellatt, PhD

Co-founder and CSO

Eva-Lotta Allan

Eva-Lotta Allan

Independent Chair

Lucy Edwardes Jones

Lucy Edwardes Jones

Non-Executive Director
BGF

Dr Tim Funnell

Dr Tim Funnell

Non-Executive Director
Monograph Capital

Dr Sohaib Mir

Dr Sohaib Mir

Non-Executive Director
LifeArc Ventures

Elena Viboch

Elena Viboch

Non-Executive Director
General Catalyst

Emma Johnson

Emma Johnson

Non-Executive Director
British Patient Capital Limited

INVESTORS

Contact

Discovering transformational therapies

admin@maxion.co.uk

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Address

The Works, Suite 4 — Unity Campus
London Road
Cambridge, CB22 3FT
United Kingdom

Arndt Schottelius, MD, PhD
John McCafferty, PhD
Aneesh Karatt-Vellatt, PhD
Eva-Lotta Allan
Lucy Edwardes Jones
Dr Tim Funnell
Dr Sohaib Mir
Elena Viboch
Emma Johnson
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